Human Reproduction

Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues.Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.

List of Papers (Total 9,882)

Early pregnancy maternal and fetal angiogenic factors and fetal and childhood growth: the Generation R Study

STUDY QUESTION What are the effects of maternal and fetal soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) concentrations on fetal and childhood growth patterns?

Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2

STUDY QUESTION Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?

A leap of faith? An interview study with professionals on the use of mitochondrial replacement to avoid transfer of mitochondrial diseases

STUDY QUESTION What are the opinions of professionals in the field of genetics, reproductive science and metabolic diseases on the development of mitochondrial replacement technologies to be used in the context of medically assisted reproduction?

Perinatal outcomes in a subsequent pregnancy among women who have experienced recurrent miscarriage: a retrospective cohort study

STUDY QUESTION Is a history of three or more miscarriages associated with adverse perinatal outcomes in a subsequent pregnancy?

The prevalence and phenotypic characteristics of spontaneous premature ovarian failure: a general population registry-based study

STUDY QUESTION What is the measured prevalence and phenotype of spontaneous premature ovarian failure (POF) in the general population?

Melanoma risk after ovarian stimulation for in vitro fertilization

STUDY QUESTION Do women treated with ovarian stimulation for IVF have an increased risk of melanoma?

Recombinant follicle-stimulating hormone and recombinant luteinizing hormone versus recombinant follicle-stimulating hormone alone during GnRH antagonist ovarian stimulation in patients aged ≥35 years: a randomized controlled trial

STUDY QUESTION Does luteinizing hormone (LH) supplementation improve live birth rate after in vitro fertilization (IVF) in patients aged ≥35 years receiving a gonadotrophin-releasing hormone (GnRH) antagonist protocol?

Medroxyprogesterone acetate impairs human dendritic cell activation and function

STUDY QUESTION Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function?

Midwives' adoption of the reproductive life plan in contraceptive counselling: a mixed methods study

STUDY QUESTION How is the reproductive life plan (RLP) adopted in midwifery contraceptive counselling?

Improving patient-centredness in partnership with female patients: a cluster RCT in fertility care

SUMMARY QUESTION What is the effect of a multifaceted intervention with participation of patients on improvement of patient-centredness in fertility care?

Psychosocial development of full term singletons, born after preimplantation genetic diagnosis (PGD) at preschool age and family functioning: a prospective case-controlled study and multi-informant approach

STUDY QUESTION Do full term singletons born after preimplantation genetic diagnosis (PGD) differ in their psychosocial functioning from children born after intracytoplasmic sperm injection (ICSI) and spontaneous conceived controls (SC)?

Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma?

STUDY QUESTION Can gonadotrophin-releasing hormone agonists (GnRH-a) preserve long-term fertility when administered prior to and concomitantly with chemotherapy?

Increased levels of dioxin-like substances in adipose tissue in patients with deep infiltrating endometriosis

STUDY QUESTION Are the levels of biologically active and the most toxic dioxin-like substances in adipose tissue of patients with deep infiltrating endometriosis (DIE) higher than in a control group without endometriosis?

The comprehensiveness of the ESHRE/ESGE classification of female genital tract congenital anomalies: a systematic review of cases not classified by the AFS system

STUDY QUESTION How comprehensive is the recently published European Society of Human Reproduction and Embryology (ESHRE)/European Society for Gynaecological Endoscopy (ESGE) classification system of female genital anomalies?

Dynamic changes in hyperglycosylated human chorionic gonadotrophin throughout the first trimester of pregnancy and its role in early placentation

STUDY QUESTION What is the in situ localization and function of hyperglycosylated hCG (hCG-H) in first trimester pregnancy tissues?

Replication and meta-analysis of previous genome-wide association studies confirm vezatin as the locus with the strongest evidence for association with endometriosis

STUDY QUESTION Is it possible to replicate the genetic association of single nucleotide polymorphisms (SNPs) rs13394619, rs4141819, rs7739264, rs17694933 and rs10859871 in five genetic loci previously identified as associated with endometriosis in an Italian Caucasian population?

Underuse of modern methods of contraception: underlying causes and consequent undesired pregnancies in 35 low- and middle-income countries

STUDY QUESTION What is the contribution of the underuse of modern methods (MM) of contraception to the annual undesired pregnancies in 35 low- and middle-income countries?

First trimester phthalate exposure and anogenital distance in newborns

STUDY QUESTION Is first trimester phthalate exposure associated with anogenital distance (AGD), a biomarker of prenatal androgen exposure, in newborns?

Amino acid composition of human uterine fluid: association with age, lifestyle and gynaecological pathology

STUDY QUESTION Do the amino acid levels of human uterine fluid vary with age, BMI, phase of menstrual cycle, benign pathology or diet?

Interaction of human trophoblast cells with gland-like endometrial spheroids: a model system for trophoblast invasion

STUDY QUESTION Do maternal endometrial epithelial cell (EEC) differentiation and polarity impact the invasive capacity of extravillous trophoblast (EVT) cells during early human implantation?