Objective: to estimate the antihypertensive, antiremodelling efficacy and clinical tolerability of the monotherapy with Zofenopril in patients with Grade 1 and 2 hypertension (HT 1 and 2) Materials and Methods: The study included 30 patients aged from 30 to 60 years with HT 1 and 2 (ESH/ESC, 2013) without severe comorbidities and cardiovascular complications. Zofenopril was...
The construction of a principled and generalized model of a mythologem (ML) as psychogenic structure having psychological, electric, magnetic, hemodynamic, and time equivalents is the result of this study. Periodic invariant sensory patterns, creating a dominant center, form a stable neural network, the result of which is an ML. Within the framework of the ML model construction...
Background: The role of subchorionic hematoma (SCH) in the first trimester of pregnancy remains open for discussion. Some authors claim that SCH does not affect the pregnancy; others have found that it is a serious risk factor for adverse pregnancy outcome. The objective of the present study was to explore the outcomes of pregnancy in patients with SCH diagnosed in the first...
Garlic has antioxidant and hypocholesterolemic properties that are attributed to its organosulfur compounds being allicin, which is reported to be the most active of these compounds. We hypothesized that allicin content could reduce plasma concentrations of triglycerides (TG), total cholesterol (TC), HDL (high density lipoproteins), VLDL (very low density lipoproteins), and...
The aim of the present study was to analyze the impact of traditional and renal risk factors (RFs) on the probability of cardiovascular death in CHD patients in the remote period after myocardial revascularization (MR). Materials and Methods: The present study included 90 CHD patients (80 men and 10 women; mean age 56.1±0.9 years) with indications for MR. The prevalence of major...
Wolff-Parkinson-White (WPW) syndrome is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. As the syndrome significantly reduces the patients’ quality of life (QoL), the purpose of the current study was to compare QoL scores in patients with WPW syndrome before and after a radiofrequency catheter ablation (RFA...
Objective: Comparative analysis of the results of the visual evoked potential investigation according to stages of optic neuritis (ON). Material and Methods: The study included 90 patients (90 eyes) with different stages of ON. A control group comprised 10 somatically healthy persons (10 eyes) of the same age without ophthalmic pathology. All examined underwent standard...
Currently, substance abuse is one of the most serious problems facing our society. The aim of this study was to investigate the clinical manifestations of the opiate withdrawal syndrome (OWS). The study included 112 patients (57 women and 55 men) aged from 18 to 64 years with opium addiction according to the DSM-IV. To study the clinical manifestation of OWS, the special 25-score...
The study aims at investigating the disturbance in intra- and extracranial interaction of arterial and venous vessels in stable arterial hypertension (SAH) and building a model of vascular relationships in the system: inflow – the exchange field of cerebral blood flow – outflow. Baseline data were obtained by catheterization through a probe that was wedged in the superior bulb of...
The purpose of the present study was to evaluate pharmacogenetic aspects of the antihypertensive, cardioprotective and vasoprotective efficacy of Indapamide in association with the ADD1 Gly460Trp polymorphism in Uzbek hypertensive patients. Materials and Methods: The study included 37 ethnic Uzbek patients (mean age of 47.14±9.54) with untreated hypertension (HT) of Grade 1 and 2...
Background: Obesity is a growing problem all over the world, including the United States. Single-incision laparoscopic sleeve gastrectomy is a surgery performed for patients who want to lose weight. The number of deaths resulting from thromboembolic complications from bariatric surgeries continues to be of major concern. Case Description: A 38-year-old female was admitted for...
Background: Point-of-care testing, POCT, was widely used to assess hemoglobin status before proceeding with the confirmation test. Our study aimed to assess the validity of Mission® Plus Hb in detecting hemoglobin levels in a general population compared with a standard laboratory hematology analyser as the gold standard. Methods: Two types of samples, capillary and venous blood...
The results of a retrospective study of newly diagnosed cases of congenital heart defects (CHDs) among liveborn infants in the Sakha Republic (Yakutia, SR(Y)) are presented. The study was divided into two time periods: Period A (from 2002 to 2002) and Period B (from 2011 to 2013). A comparative analysis of the prevalence of CHD detection and the structure of clinical entities of...
The aim of our study was to quantify serum hepcidin levels in Bulgarian patients with chronic kidney disease (CKD). Expected high values of peptide hormones might provide a new therapeutic choice for anemia of chronic disease. We looked for correlation between serum hepcidin levels and some iron metabolism parameters in CKD patients. Results: The sandwich ELISA is highly specific...
The aim our study was to evaluate the levels of zinc in blood serum, hair, and specimens of carotid artery atherosclerotic plaques (CAAPs) and their relationship to levels of MMP-9 and TIMP-1 in the serum of patients with stable and unstable CAAPs. Material and Methods: The study included 73 patients (55 men and 18 women) aged from 46 to 88 years (mean age 65.96±1.07 years) with...
In recent years, fall from a height (FFH) has been a relatively frequent cause of injury and death in the urban environment. The purpose of this study was to optimize the risk stratification of FFH victims with combined injuries of the abdominal organs by using Injury Severity Score (ISS) scale. The study included 111 patients (aged between 15 and 80 years) injured by FFH. All...
This article analyzes the results of a clinical examination of 102 patients (78/76.47% men and 24/23.53% women) with a brain tumor (BT) complicated with a secondary obstructive hydrocephalus (SOH). All the patients were divided into 3 groups according to the type of surgery. Group I included 38(37.2%) patients who underwent Torkildsen's ventriculocisternostomy. Group II consisted...
There is so much health and medical information available today that physicians cannot be expected to know it all. Thus, advances in technology have become a necessity for doctors to track patient information and care, and add to patient databases for reference and to conduct research. It is important to understand the new language of digital health, such as Personal Health...
Objective: The aim of our study was to evaluate the association between cytochrome P450 2C19 (CYP2C19) 681G>A polymorphisms and the age of development of coronary heart disease. Additionally, the study might find some biological indicators at the gene level that could help to predict and evaluate the risk of coronary heart disease in time. Methods: This study included 352...
Derangements of phenylalanine and tyrosine metabolism are an important factor in the etiology and pathogenesis of psychoneurological disorders. These disorders are particularly pronounced with monogenic hereditary diseases. In this work, we investigated similar disturbances in widespread and socially significant diseases – viral hepatitis and chronic alcoholism – which are...
In the present review, we set out a new high-tech method for determining the major metabolites of catecholamines and serotonin in urine. We then discuss the effects of these substances and the value of their main metabolites in normal and various pathological conditions, and show the efficiency of applying this technique in the laboratory diagnosis of several diseases.
The aim of our study was to determine the degree of sensitization to Alternaria alternata in patients with chronic obstructive pulmonary disease (COPD) and perennial allergic rhinitis (PAR), and evaluate the effectiveness of SIT in patients sensitized to Alternaria alternata. Material and Methods: All patients were divided into two groups. Group 1 included 130 patients (53 women...
The aim of the present study was to examine the surface characteristics and values of removal torque of an implant surface subjected to sandblasting with 125µm Al2O3 particles with a following immersion in biomimetic fluid and to compare that surface with a machined implant surface. Study protocol: Forty-eight conical implants were initially made of second-grade titanium alloy...
The objective of study was to improve the results of surgical treatment of patients with bilateral atherosclerotic lesions of the carotid arteries. Material and Methods: The study included 180 patients between the ages of 42 and 82 (mean age 59±5.6 yrs) who underwent surgical treatment for bilateral atherosclerotic lesions of the carotid arteries during 2008-2014. Depending on...
Characteristics of the modulated ultrasound effect (range of modulation frequencies 10Hz–1000Hz intensity 0.2 W/cm2) on white blood cells (WBCs) from different animals were studied. The quantitative ratio of WBCs was the most strongly altered by ultrasonic modulation frequency 1000 Hz. This frequency led to degenerative changes of cells. The presence of non-typeable or destroyed...