The aim of the present study was to examine the factors of prognosis in patients with malignant pleural mesothelioma (MPM) after combined and multimodality treatment, including the prognostic significance of preoperative intrapleural perfusion hyperthermo-chemotherapy (IPHC). Material and Methods: The study included 20 patients (11 men and 9 women) aged from 30 to 70 years (mean...
The Ross procedure (RP) is considered by many authors as the best option for aortic valve replacement in young children and adolescents. This paper presents the results of the immediate and late postoperative period (more than 5 years) after the RP among pediatric patients.
The aim of this study was to investigate the frequency and spectrum of KRAS mutations in men and women with colorectal cancer (CRC), and an impact of KRAS-mutation status on the clinical and morphological features of CRC. The study included 303 patients (168/55.4% women and 135/44.6% men) with CRC T2-4N0-2M0-1. We defined 7 KRAS SNP-mutations (G12D, G12A, G12R, G12C, G12S, G12V...
Objective: to study the changes in the expression level of the subset of genes, encoding for important cell growth factors and enzymes, which play an important role in the control of cellular growth and apoptosis, in blood cells of obese boys with and without insulin resistance for evaluation of its possible significance in the development of obesity and impaired insulin...
This report presents a clinical case describing successful endovascular transplantation of autologous bone marrow mesenchymal stem cells (MSCs) into liver of a patient with liver cirrhosis.
The aim of our work was to study anthropometric characteristics of jaws for Uzbek people with an orthognathic bite. Material and Methods: The study included 42 ethnic Uzbeks (20 women and 22 men) aged from 17 to 25 years with a developed orthognatic bite; the control group consisted of the 25 age- and sex-matched Caucasians and Southern Altaians (mongoloids). The object of the...
Background: A molecular approach to estimation of local inflammatory response associated with dysbiotic conditions of the vagina is reported. This approach is based on immune response gene transcription levels measured by qPCR assay. Methods and Results: qPCR analysis of 24 immune response gene transcripts in vaginal smears was performed for 215 women with vaginitis and 95...
The quest to optimize cancer treatments and to extend cancer survival is consistently thwarted by an unavoidable but expected consequence – mucositis of the oral and gastrointestinal tract. Prior to market approval our Translational Medicine Research Center clinically tested polymerized cross-linked sucralfate (PCLS) on a cancer treatment patient who underwent 6 weeks chemo...
Purpose: This study aims to evaluate the effectiveness of OK-432 immunotherapy in the treatment of lymphatic malformation (LM) in children and to determine its complications and contraindications. Methods: Twenty-eight patients with LM of head and neck were enrolled. Twenty-three (82.2%) patients were treated with OK-432 immunotherapy, and surgery was performed in 5 (17.8%). LMs...
Numerous studies have indicated that aggression and homicide are more frequent among people with schizophrenia than in the general population. There is considerable evidence that schizophrenia involves a dysbalance between subcortical and cortical dopaminergic systems. The major pathways for catecholamine degradation are oxidative deamination through the action of monoamine...
The efficiency of the laser light-emitting diode (LED) that is used in the complex treatment of acne was studied with light microscopy, scanning electron microscopy, and planimetry. It was found that the light emission of the photon matrix by A.Korobov–B.Korobov “Barva-Fleks/BIR” (λ1=470nm and λ2=940 nm) combined with the drug treatment are an effective means for the treatment of...
MDR1 gene C3435T and C1236T single-nucleotide polymorphisms (SNPs) have been studied in 59 Uzbek patients with epilepsy aged from 1 to 40 years. The patients were resistant to anticonvulsant drugs in therapeutic doses with no remission attained. The disease duration was about two years. The DNA samples were isolated from peripheral blood of patients and healthy individuals. The...
A total of 230 children having bronchopulmonary pathology (BPP) were examined. Patients were divided into 4 groups according to their intraerythrocyte non-protein- bound iron (IE-NPBI) levels. We investigated the relationship of the IE-NPBI level with parameters of respiratory function (RF) tests, the severity of comorbidities, and level of other free intracellular ions, such as...
The purpose of the present research was to study the comparative influence of lisinopril and losartan on the parameters of cardiac hemodynamics and kidney function state in CHF (Congestive Heart Failure) patients with NYHA Functional Class (FC) I-III. Material and Methods: The study included 92 CHF patients between the ages of 41 and 75 (mean age 66.3±9.8 yrs) with FCI-III of...
The impression oral mucositis is a brief consequence of chemoradiation is misguided. Patient-reported clinically significant oral mucositis may last 46 to 102 days depending on the cancer treatment, and may possibly be avoided with polymerized cross-linked sucralfate.
Carcinoma gall bladder is a very aggressive disease with poor outcomes. Despite achievements in the field of advanced imaging techniques, there is a very high mortality rate of the disease Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 million deaths per year. The magnitude of cancer problem in the Indian Sub-continent (sheer...
Background: Limb girdle muscular dystrophies (LGMDs) and several other disorders which share their specific phenotype are rare, predominantly hereditary conditions with no curative treatment. Differential diagnosis of these myopathies is quite challenging and expensive in many cases. Therefore, a significant proportion of patients remains undiagnosed and untreated for a long time...
The aim of this research was to develop a method for noninvasive staging of liver fibrosis (LF) in patients with chronic hepatitis C (CHC) based on ultrasound imaging (UI) of the abdominal cavity. We examined 124 patients with CHC. The diagnosis was verified on the basis of clinical and epidemiological, serological and molecular biological data. Direct ultrasonic parameters of...
The purpose of this study was to examine the impact of radiofrequency electromagnetic fields (RF-EMFs) on platelet aggregation (PA) in individuals working for a long time under a direct and continuous RF-EMF exposure. We examined 119 persons aged from 22 to 65 years. In individuals working under the direct and constant exposure to RF-EMFs, the various changes of PA with a...
Aim: To evaluate the efficacy of a high dose (4g/day) of omega-3-PUFA on the heart rate variability (HRV) characteristics in patients with acute myocardial infarction (AMI) and Type 2 Diabetes Mellitus (T2DM) Material and Methods: The study included 93 patients with AMI and concomitant T2DM during the first 48 hours from the onset of the disease. Group 1 comprised 40 patients...
CMV infection during pregnancy induces a number of N-nitrosation reactions in erythrocytes, which violate process of normal hemoglobin oxygenation. Abnormalities in the L-arginine-NO system cause a decrease in the antioxidant capacity of red blood cells, which is associated with reducing the amount of glutathione reductase, glutathione peroxidase and superoxide dismutase.
The review aims to analyze the relationship between metabolic changes in muscle tissue occurring in space flight conditions and other body systems during the developing atrophy. The data about the activity of various enzyme systems in muscles, liver and myocardium are presented. It was shown that during the transformation of postural muscles, metabolism from the lipid to...
Background: We analyzed the correlation between several factors (donor age and gender, and handling time) and trace DNA concentration that participants left on different surfaces (paper, plastic, plastic coated metal) while holding items in their hands or rubbing them with their fingers, their palms, and the side of the palm of the dominant hand. Material and Methods: Sixty...
The ecological model of modern medicine has acquired a new quality and has become one of the leading models. In this regard, the establishment of ecological and biogeochemical determinants of health is a real problem. Along with the socio-economic and environmental-demographic challenges of the North development, the health issue takes a crucial place. The Yakutia population has...
The aim of our work was to study the neurological status and cognitive function in patients with stage I and II CCI, depending on its nature. Material and Methods: The study included 302 patients (mean age - 61.3±0.3 years; 165/54.6% men and 137/45.4% women) with stage I and II CCI. Clinical and neurological examination, study of cognitive function, and MRI were performed in all...