The aim of this study was to determine the effect of a prolonged high-fat (HF) on thiol-disulfide homeostasis via the activity of the glutathione redox-system (GRS) in rat blood and liver. Methods: The experiment was conducted on male Wistar rats. They were divided into groups and fed on the HF diet for 30, 90 and 180 days, respectively. The HF diet consisted of beef fat and...
Background: Adenomyosis is a very real problem encountered in modern gynecology due to the increase in the incidence, severity of the disease, and absence of effective methods of conservative treatment. The aim of the study was to investigate the clinical and morphological features of the focal and diffuse forms of adenomyosis. Methods and Results: The study involved 70 women who...
Chronic cytomegalovirus (CMV) infection in pregnant women is accompanied by the accumulation of large amounts of the circulating immune complexes (CIC) in the peripheral blood. On reaching the placental villous syncytiotrophoblast, the CIC induce a concentration of lysosomes of the syncytiotrophoblast cytosol on the outer membrane of the fetoplacental barrier. Contact between the...
The objective of this study was the investigation of the influence of ureaplasmal infection on the development of urethral meatus polyps in women. The article presents the results of the examination of women with chronic cystitis and urethritis over a 0.5- to 5-year duration, complicated by the presence of urethral meatus polyps and associated with concomitant Ureaplasma...
In this article, we review the neurophysiology of the bladder and the lower urinary tract function and discuss logical concepts for the development of novel drug therapy for patients with lower urinary tract dysfunction.
Human red blood cells (RBCs) when suspended in a Low Ionic Strength medium (LIS) demonstrate characteristic triphasic shape changes (morphological response, MR) and become reduced in volume. Tahitian Tabari Noni juice (Tb), after being given during the terminal phase of MR, was shown to initiate an unusual cell response. This response can be described as a volumetric four-phasic...
This is the report of a 59-year-old woman suffering from recurrent vaginal pain and bleeding and episodes of anal bleeding. At the age of 16 she underwent vaginal plastic surgery. The case demonstrates the ulcerative engagement of the vaginal transplant.
In total, 57 patients (31 males and 26 females) with diabetic nephropathy were studied on a comparative basis to observe the renoprotective effectiveness of eprosartan mesylate and lercanidipine. Eprosartan mesylate revealed a higher nephroprotective effect compared with lercanidipine at comparable antihypertensive effects of equivalent doses of both these preparations.
Background: In dental practice concomitant exposure to formaldehyde and glutaraldehyde is a common occurrence. The objective of the study is to evaluate the incidence of occupational contact dermatitis to formaldehyde and glutaraldehyde in dental professionals and the manifestation of co-reactivity. Methods and Results: This study involved 78 participants (30 dental professionals...
Objective: The aim of this study was to investigate the relationship between the risk of aggressive behavior recidivism and poor executive functioning in a forensic setting in schizophrenic patients. Methods: The data were collected over a two-year time period. The subjects in the study included 65 male adults ≥18, with schizophrenia disorder using SCID based on the DSM-IVR...
This article presents the results of the surgical treatment of the posterior urethral valves (PUV) in 58 children (between 2 months and 15 years of age), between 1998 and 2009. In all, 26 patients were treated using the endoscopic method (EM) and 32 patients were treated by the proposed method, using a metallic urethrotome (MU). Diagnosis of the urethral valves was done using...
The present research aimed at studying the atrial and brain natriuretic peptide (NUP) levels in the blood plasma of patients with Metabolic Syndrome (MS). The research includes 52 patients in total, of which 40 patients with MS constitute the observation group while 12 conventionally healthy people comprise the control group. An increase in the NT-proBNP at 20% (p<0.05) and...
The characteristic features of the cord blood and endothelium of the umbilical vessels from newborns delivered by mothers experiencing an exacerbation of chronic cytomegalovirus (CMV) infection during gestation has been studied. Exacerbation of the chronic CMV infection was found to increase during pregnancy and sharply affect the function of gas transport in both the maternal...
The microbiological synthesis of [2H]amino acids was performed by the conversion of low molecular weight substrates ([U-2H]MeOH and 2H2O) using the Gram-positive aerobic facultative methylotrophic bacterium Brevibacterium methylicum, an L-phenylalanine producer, realizing the NAD+ dependent methanol dehydrogenase (EC 1.6.99.3) variant of the ribulose-5-monophosphate (RuMP) cycle...
In patients with uveitis of infectious etiology, a significant increase in the index of intoxication and acute inflammation (the Leukocyte Intoxication Index -LII), by 3.4 times on average, was observed. At the same time, this increase in the LII index, in our opinion, was due to the decrease in the percentage of eosinophils in the blood, which in turn increased the number of...
A detailed study of the dynamics of leptin in the various types of disturbances in carbohydrate metabolism could reveal its role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). The aim of this study was to investigate the Fasting Leptin Level (FLL) and effect of acute hyperinsulinemia during the Intravenous Glucose Tolerance Test (IVGTT) on the leptin levels in women with...
Experiments were conducted to study the benefit of using the new plant growth regulators (PGRs) Ivin, Emistim, Biolan and Charkor in nutrient medium ½ MS for intensification of biomass growth and the increased synthesis of polyfructan (PF) in the cultures of chicory “hairy roots” (Cichorium intybus L.), obtained by Аgrobacterium rhizogenes-mediated transformation,. The best...
The aim of this study was to assess the profile of mucins (MUC1, MUC2, MUC5AC) in the intestinal metaplasia (IM) of the gastric mucosa through the immunohistochemical method. Methods: To identify the metaplastic areas in the gastric mucosa, chromoendoscopy was employed using 0.5% solution of methylene blue. The expression of the profile of the mucins was determined using...
Twenty four patients with lung metastases underwent radiosurgery treatment between October 2010 and December 2012. Stereotactic conformal high-dose radiation therapy with Active Breathing Control (ABC) was conducted using the volumetric modulated arc therapy (VMAT) technique. The median overall follow-up was 18 months (range 6-24 months), overall survival was 75%, and local...
Background: Aging is associated with an increased hypercoagulable state. Degenerative diseases of the large joints are also accompanied by increased coagulation activity. We investigated the effect of age on the hemostatic function in patients with osteoarthritis. Material and Methods: The study included 192 patients with osteoarthritis admitted to the clinic for primary hip or...
Background: The aim of our study was to examine the possibility of ventricular extrasystole (VES) management in CAD (coronary artery disease) patients by attenuating the sympathetic activity with a course of electrical stimulation of the vagus nerve. Methods: A decrease in sympathetic tone was achieved via vagus nerve electrical stimulation (VNES). VNES was performed in 48 male...
An analysis of the capabilities of cone-beam computed tomography (CBCT) in the assessment of the form and structure of wrist and hand bones was the aim of the research. Cone-beam CT of wrist and hand was conducted in a group of voluntary patients, which included 40 members aged 22- 68 years. Magnetic resonance imaging (МRI) was carried out in 80.0% (n = 32) of cases, multislice...
Every creature is good and subject to the principle of solidarity that everyone has been blessed and gifted with life by God. Therefore, we cannot have one without the other, and no man exists without an animal.Over the last several decades, our world has been confronted with many ethical problems and ethics is being more and more sought after in spheres of human conduct and...
Breast cancer is one of the major surgical problems encountered in Libya. Lactic acidosis is a universal complication in breast cancer patients and can be considered a possible prognostic marker. Therefore, it will be beneficial to correctly understand and review the biochemistry underlying lactic acidosis and its possible significance as a prognostic marker in critical care...
Reduced mineral content affects the trabecular microstructure in the jawbones and skeletons of animals. The aim of this study was to ascertain the benefits in terms of increased bone density in the region of the lateral teeth in the upper and the lower rabbit jaws after application of a therapeutic solution of calcitonin and calcium. The solution was injected to the right side of...