This study found that value of the carbon dioxide (CO2) tension in the capillary blood of Arctic inhabitants is lower during the winter, whereas the CO2 levels in the atmosphere are lower in the summer. This study also revealed that the heart rate and respiratory minute volume in the Arctic inhabitants are significantly higher in the winter, while the respiratory rate and cardiac...
In this paper, the method developed to suture liver wounds is described in detail. The results of the surgical treatment of liver laceration with blunt abdominal trauma during the period 2001-2012 are presented. The technique developed for suturing liver wounds in patients with blunt abdominal trauma was evaluated. The method developed involving suturing of the liver wounds in...
In this article, the problems encountered in the rational use of drugs are discussed, one of the areas of optimization of drug supply being the rational choice of drugs, particularly, a regulatory activity regarding the approach to the selection of standardized drug lists (drug formulary) for public drug supply, according to government guarantees and programs. The clinical...
There is no scientific data on the molecular mechanisms of reproductive aging in women. The purpose of the study is the development of molecular phenotypes of the aging in women with gynecologic pathology of reproductive and post-reproductive periods. The present study included 90 women with subfertility of varying degrees of severity and infertility. All the patients were...
In this paper, the features of joint lesions in women with co-morbidity of osteoarthritis and osteoporosis based on the constitution were presented. It was found that the combined lesions of the knee joints with the small joints of the hands, knee joints combined with the first metatarsophalangeal joint, as well as isolated osteoarthritis of the knee joint were significantly more...
The prediction and diagnosis of thromboembolic complications in extensive orthopedic surgery pose a serious problem. Solving this problem becomes important in the study of the functioning of the hemostatic system. The study of the functioning hemostatic system is important for solving this problem. We investigated the effect of the pre-operative activity of fibrin formation and...
The clinical and experimental efficiency of the soft-start polymerization technique in composite restorations was studied. In this study, 57 patients between 30 and 44 years of age with secondary caries had 158 restorations done using the photo-composite material Filtek Z250. The restorations performed were distinguished into two groups, the basis of the photo-polymerization...
Obesity is a global epidemic characteristic of the 21st century; therefore, studying the subclinical markers of coronary atherosclerosis in overweight patients is current and relevant. With weight increase, hypertrophy and hyperplasia of adipocytes occur not only in the abdominal area, but also in the ectopic local fat depots, including the epicardial ones. As the myocardium and...
The objective of this study was the investigation of the influence of chlamydial, mycoplasmal and trichomonas infection on the development of urinary bladder leukoplakia. The article presents the results of the examination of women with chronic cystitis complicated with leukoplakia of the bladder, and associated with concomitant sexually transmitted infections, including the...
In the lung, the pathogenesis of emphysema (Em) is complicated and involves several endogenous factors: protease-antiprotease imbalance, α1-antitrypsin deficiency, oxidative stress (OS), and ion imbalance. It is our contention that an increase in the free Fe level in combination with a significant decrease of SOD activity that we detected is disadvantageous for patients with lung...
The majority of the studies in the field of childhood asthma lie within the scope of allergy/atopic asthma; however, airway hyperresponsiveness is considered a marker of asthma, independent of the atopic status and should be regarded as a parallel pathological process that can lead to subsequent symptoms and clinical evidence of asthma in children, without the evidence of atopy...
This study helped to ascertain the superiority of Diaskintest® (DST) with respect to the wealth of information it provides when compared with the Mantoux test with PPD 2 TU (M2) in determining the activity of tuberculosis infection in children. The evaluation parameters of diagnostic value with DST (DE=77.5%, NPV=72.4%, PPV=91.1%) were significantly higher than with M2x test 2TU...
Human herpes virus (HHV) infections are dangerous during the early stages of pregnancy. Circulatory disorders of theendometrium from the uterine arteries pose a threat to the implantation of the embryo and the formation of the structure of chorionic villi. Oxygenation of the placental blood gets disrupted.
The ethnic people of the Republic of Khakassia (the Khakas) with ulcer disease show a significant T-cell activation and humoral immune response when compared with the Europoids. The reasons for such differences could be due to certain ethno-specific allelic variants of the interleukins, which considerably change the degree of cytokine expression. The aim was to study the...
The association between hemodynamic and biochemical parameters of cerebral blood flow have been studied in man, using mathematical methods of statistics. The values have been obtained through catheterization using a probe jammed at the level of the bulb of the superior jugular vein. Relationships with central hemodynamic parameters have been evaluated, including the right atrium...
The present study was conducted to examine the interaction of biochemical parameters within the blood flow, their effect on the cerebral blood flow, as well as the mechanisms of cerebral ischemia by stable arterial hypertension. The hemodynamics and biochemical indicators of cerebral blood flow without the additives of the extracranial blood were obtained by the catheterization...
Objective: To identify individuals at high cardiovascular risk (CVR) to check for an additional estimate of CVR with the use of the ESH/ESC Guidelines (2003, 2007) in patients earlier classified as being at low and moderate risk on «SCORE». Material and methods: The study included 600 people (155 men and 445 women) with low and moderate cardiovascular risk on the SCORE scale. All...
The quality of life in was analyzed in 248 patients with liver cirrhosis with portal hypertension after portosystemic shunting. All patients underwent decompressive surgery options, in 135 cases - a selective distal splenorenal anastomosis, in 113 cases- different versions of the central decompression. In the study used a questionnaire developed by Younossi ZM et al. (1999) for...
Metabolic and hemodynamic disturbances in newborns with intrauterine growth retardation resulting from the transferred intrauterine hypoxia, lead to the development of transient myocardial ischemia. Study included 158 newborn infants with intrauterine growth retardation, 83% of which have the asymmetric and 17% - the symmetric form of IUGR, revealed differences in heart rate due...
Results of a multicenter study of the frequency of reinterventions after emergency abdominal operations in various segments of the surgical service presented. Study included three groups, where the first group consisted of patients operated at the V.Vahidov Republican Specialized Center of Surgery (252 patients), the second group - 176 patients treated in regional and urban...
In this study, mesial temporal lobe epilepsy (MTLE) is shown to be associated with human herpes virus (HHV) neuroinfections. We also demonstrate that the epileptic process is associated with an inflammatory reaction, and that the proinflammatory cytokine, the tumor necrosis factor-alpha (TNF-α) is able to potentiate the reproduction of the herpesviruses. The study group (SG...
The article deals with PYY3-36 level in the blood serum of patients suffering from exogenous constitutional obesity and overweight, as well as its role in the process of the body mass growth. Among the 327 patients diagnosed with obesity and overweight, particularly those with Class I and II degrees of obesity (p<0.05) showed a significantly increased level of PYY 3 -36. The...
Currently, there is an alarming increase in the syphilis rates accompanied by a proportional rise in the incidence of latent forms of the disease among the population of several countries. Latent syphilis considerably delays timely detection, diagnosis and, therefore, the specific early treatment of patients. In 2007, the proportion of latent forms of syphilis in the Russian...
In human heart failure, Ca2+ homeostasis gets disturbed due to a decrease in the function of the sarcoplasmic reticulum (SR). We studied the differences in the SR function in patients with rheumatic and coronary heart disease, against the background of amiodarone. Cardiac preparations from the atrium of 21 patients with coronary artery disease (CAD) and 14 patients with rheumatic...
The present paper demonstrates the effect of ASA and its combination with SUC on the energy-producing system of rat heart mitochondria as well as an assessment of SUC preventive application effect on ASA pharmacokinetic parameters. Experiments conducted on outbred male albino rats (200-250 g) on a model of a xenobiotic load induced by seven days of intragastric injections of...