Nature Communications

http://www.nature.com/ncomms

List of Papers (Total 7,162)

Fossilization transforms vertebrate hard tissue proteins into N-heterocyclic polymers

Vertebrate hard tissues consist of mineral crystallites within a proteinaceous scaffold that normally degrades post-mortem. Here we show, however, that decalcification of Mesozoic hard tissues preserved in oxidative settings releases brownish stained extracellular matrix, cells, blood vessels, and nerve projections. Raman Microspectroscopy shows that these fossil soft tissues are...

All-optical nonequilibrium pathway to stabilising magnetic Weyl semimetals in pyrochlore iridates

Nonequilibrium many-body dynamics is becoming a central topic in condensed matter physics. Floquet topological states were suggested to emerge in photodressed bands under periodic laser driving. Here we propose a viable nonequilibrium route without requiring coherent Floquet states to reach the elusive magnetic Weyl semimetallic phase in pyrochlore iridates by ultrafast...

Direct electric field imaging of graphene defects

Material properties are sensitive to atomistic structure defects such as vacancies or impurities, and it is therefore important to determine not only the local atomic configuration but also their chemical bonding state. Annular dark-field scanning transmission electron microscopy (STEM) combined with electron energy-loss spectroscopy has been utilized to investigate the local...

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

Scanning probe microscopy provides a unique window into the morphology, mechanics, and structure of proteins and their complexes on the nanoscale. Such measurements require, however, deposition of samples onto substrates. This process can affect conformations and assembly states of the molecular species under investigation and can bias the molecular populations observed in...

Mapping of histone-binding sites in histone replacement-completed spermatozoa

The majority of histones are replaced by protamines during spermatogenesis, but small amounts are retained in mammalian spermatozoa. Since nucleosomes in spermatozoa influence epigenetic inheritance, it is important to know how histones are distributed in the sperm genome. Conflicting data, which may result from different conditions used for micrococcal nuclease (MNase) digestion...

An interstellar synthesis of phosphorus oxoacids

Phosphorus signifies an essential element in molecular biology, yet given the limited solubility of phosphates on early Earth, alternative sources like meteoritic phosphides have been proposed to incorporate phosphorus into biomolecules under prebiotic terrestrial conditions. Here, we report on a previously overlooked source of prebiotic phosphorus from interstellar phosphine...

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Self-interacting chromatin domains encompass genes and their cis-regulatory elements; however, the three-dimensional form a domain takes, whether this relies on enhancer–promoter interactions, and the processes necessary to mediate the formation and maintenance of such domains, remain unclear. To examine these questions, here we use a combination of high-resolution chromosome...

Forward models demonstrate that repetition suppression is best modelled by local neural scaling

Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to fMRI responses, to see which best predicts fMRI data. We use this approach to compare four possible neural mechanisms of fMRI adaptation to repeated...

A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced allosteric activation, imaging collective EGFR activation in cells and molecular...

Reconfiguring surface functions using visible-light-controlled metal-ligand coordination

Most surfaces are either static or switchable only between “on” and “off” states for a specific application. It is a challenge to develop reconfigurable surfaces that can adapt to rapidly changing environments or applications. Here, we demonstrate fabrication of surfaces that can be reconfigured for user-defined functions using visible-light-controlled Ru–thioether coordination...

Beaming random lasers with soliton control

Random lasers are resonator-less light sources where feedback stems from recurrent scattering at the expense of spatial profile and directionality. Suitably-doped nematic liquid crystals can random lase when optically pumped near resonance(s); moreover, through molecular reorientation within the transparency region, they support self-guided optical spatial solitons, i.e., light...

The shape of watersheds

Since the 1950s river networks have been intensely researched in geosciences and hydrology. This led to the definition of scaling laws that described the organisation of landscapes under fluvial incision and were later explored by statistical physics and fractal mathematics. The emblematic Hack’s Law proposes a power-law relationship between watershed area and main stream length...

rec-YnH enables simultaneous many-by-many detection of direct protein–protein and protein–RNA interactions

Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interactions within protein libraries or between protein libraries and...

A self-improving triboelectric nanogenerator with improved charge density and increased charge accumulation speed

Charge density is one of the most important parameters of triboelectric nanogenerators since it directly determines performance; unfortunately, it is largely restricted by the phenomenon of air breakdown. Here, we design a self-improving triboelectric nanogenerator with improved charge density. A maximum effective charge density of 490 μC m−2 is obtained, which is about two times...

New suspension-feeding radiodont suggests evolution of microplanktivory in Cambrian macronekton

The rapid diversification of metazoans and their organisation in modern-style marine ecosystems during the Cambrian profoundly transformed the biosphere. What initially sparked this Cambrian explosion remains passionately debated, but the establishment of a coupling between pelagic and benthic realms, a key characteristic of modern-day oceans, might represent a primary ecological...

Abrupt drainage basin reorganization following a Pleistocene river capture

River capture is a dramatic natural process of internal competition through which mountainous landscapes evolve and respond to perturbations in tectonics and climate. River capture may occur when one river network grows at the expense of another, resulting in a victor that steals the neighboring headwaters. While river capture occurs regularly in numerical models, field...

UPF1-like helicase grip on nucleic acids dictates processivity

Helicases are molecular engines which translocate along nucleic acids (NA) to unwind double-strands or remodel NA–protein complexes. While they have an essential role in genome structure and expression, the rules dictating their processivity remain elusive. Here, we developed single-molecule methods to investigate helicase binding lifetime on DNA. We found that UPF1, a highly...

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a...

Nanomaterials design for super-degenerate electronic state beyond the limit of geometrical symmetry

Spherical atoms have the highest geometrical symmetry. Due to this symmetry, atomic orbitals are highly degenerate, leading to closed-shell stability and magnetism. No substances with greater degrees of degeneracy are known, due to geometrical limitations. We now propose that realistic magnesium, zinc, and cadmium clusters having a specific tetrahedral framework possess anomalous...

Triboelectric microplasma powered by mechanical stimuli

Triboelectric nanogenerators (TENGs) naturally have the capability of high voltage output to breakdown gas easily. Here we present a concept of triboelectric microplasma by integrating TENGs with the plasma source so that atmospheric-pressure plasma can be powered only by mechanical stimuli. Four classical atmospheric-pressure microplasma sources are successfully demonstrated...

Nonlocal electron correlations in an itinerant ferromagnet

Our understanding of the properties of ferromagnetic materials, widely used in spintronic devices, is fundamentally based on their electronic band structure. However, even for the most simple elemental ferromagnets, electron correlations are prevalent, requiring descriptions of their electronic structure beyond the simple picture of independent quasi-particles. Here, we give...

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

The motile characteristics and mechanisms that drive the dissemination of diffuse large B-cell lymphoma (DLBCL) are elusive. Here, we show that DLBCL initiates dissemination through activating STAT3-mediated amoeboid migration. Mechanistically, STAT3 activates RHOH transcription, which competes with the RhoGDP dissociation inhibitor RhoGDIγ to activate RhoA. In addition...

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Seven human isoforms of importin α mediate nuclear import of cargo in a tissue- and isoform-specific manner. How nuclear import adaptors differentially interact with cargo harbouring the same nuclear localisation signal (NLS) remains poorly understood, as the NLS recognition region is highly conserved. Here, we provide a structural basis for the nuclear import specificity of W...