Supramolecular dye polymers for aggregation-induced photocatalysis

Aggregation can profoundly alter the excited-state properties of organic chromophores; however, crystalline supramolecular polymers are often targeted for photocatalytic conversion of solar energy due to favourable charge delocalization or exciton transport. Here we exploit aggregation as a strategy for organic chromophore rigidification to activate photocatalysis by stabilizing...

Evaluating perfusion and metabolic responses of microvascular free flaps to ischemia, reperfusion and fluid resuscitation during septic shock in a large animal model

Microvascular free flap transfer is an essential procedure in head and neck reconstructive surgery, with total flap loss representing the primary complication. Sepsis has been identified as a critical risk factor contributing to flap failure. Here we aimed to evaluate the impact of septic shock on free flap vitality using a large animal model and further investigated the flap...

Author Correction: The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types

Differential assembly of mouse and human tumor microenvironments

Mouse models are frequently used to develop treatments for human cancer. However, the degree to which their tumor microenvironments (TMEs) are synonymously assembled is particularly poorly characterized. Through systematic immunoprofiling of 15 commonly used mouse models, we found that most murine TMEs recapitulate the composition of poorly infiltrated human tumors, extensively...

Publisher Correction: Multiomics characterization of an alcohol-induced hepatocellular carcinoma mouse model

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

Inflammatory responses are associated with recruitment of monocyte-derived cells (Mdcs) into tissues. Although tissue-specific Mdc reprogramming is well established, how Mdc infiltration alters tissue metabolism remains unclear. Here, using a mouse neuroinflammation model coupled with genetic fate mapping, metabolomics and metabolite imaging, we identify that central nervous...

A synthetic cell microreactor with two types of interacting dynamic DNA-based pores

Reconstructing cellular complexity is a central challenge in synthetic biology, with profound implications for understanding life and advancing bio-inspired nanotechnologies. A critical step towards this goal is replicating the dynamic interplay among membrane components and their functions. Here we demonstrate a double-necked synthetic cell microreactor (DCM) that incorporates...

What’s in a NAM?

The transition away from animal experimentation is gaining momentum across scientific disciplines, driven by technological advancements, ethical imperatives and policy support. At the forefront of this movement is the development of New Approach Methodologies (NAMs). Rather than serving as mere substitutes for animal testing, NAMs represent a paradigm shift. Their growing...

Author Correction: Early methionine availability attenuates T cell exhaustion

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten

Celiac disease (CeD) is an autoimmune disorder triggered by dietary gluten. While HLA-DQ2/8-mediated presentation of gliadin peptides is required for disease, the mechanisms that underlie the loss of oral tolerance to gluten remain incompletely understood. Long-noncoding RNAs (lncRNAs) have been increasingly recognized as regulators of immune function, yet their role in oral...

Sex-specific systemic and brain metabolic responses to a standardized ketogenic diet in mice

Ketogenic diets (KDs) are widely used in preclinical research to investigate metabolism and neurological function, yet many studies lack methodological consistency and frequently exclude female animals. Here we investigated sex-specific systemic and brain metabolic responses to a standardized KD in mice, highlighting the need to include both sexes. Using the widely used C57BL/6J...

IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma

Allergic asthma is driven by type 2 immune responses, including type 2 innate lymphoid cells (ILC2s). Although ILC2s are activated by the tissue alarmins interleukin (IL)-33 and IL-25, these signals do not intrinsically enforce type 2 identity and the mechanisms that maintain type 2 cytokine expression remain unclear. Here we show that allergen-induced IL-33 and IL-25 rapidly...

Publisher Correction: Unlocking chemical diversity in aptamers with DNA orthogonal barcodes

Alternative antibiotic regimens improve palatability and welfare in mice for gut bacterial depletion

Here we evaluated vancomycin–neomycin or enrofloxacin–ampicillin treatments as alternatives to the poorly tolerated ampicillin–metronidazole–vancomycin–neomycin cocktail for gut bacterial depletion in mice. Both regimens were well tolerated in drinking water and did not reduce food intake or body weight. Metabolic profiling showed reduced bacterial metabolic activity in both...

Author Correction: Chemokine-defined macrophage niches establish spatial organization of tumor immunity

BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition

Germinal center B cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1, are known. We reveal an unsuspected role for BLIMP1 (Prdm1)—a plasma cell determinant—as a feedback regulator of affinity maturation. Single-cell RNA and B cell receptor (BCR) sequencing showed that B cell-specific...

Moving beyond oral gavage: micropipette-guided drug administration (MDA) as a 3R refinement for voluntary oral drug delivery in rodents

Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets

Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice...

Transforming our future by unlocking the power of DNA: the representation of health-related genomic testing in UK news items

Many people will have had no formal education on health-related genomic testing, so information from media sources may constitute a major influence in shaping ideas and expectations around genomic tests. We undertook a framing analysis of 186 UK news items discussing health-related genomic testing in the context of various recent UK-based initiatives: the 100,000 Genomes Project...

Modeling of complex physical and biological problems using bi-univalent function calculus

In recent years, bi-univalent functions and fractional calculus have attracted considerable attention due to their strong theoretical foundations and potential applications in applied sciences. However, most existing studies focus primarily on coefficient estimates from a purely theoretical perspective, with limited attention given to practical physical or biological...

Oxygen stoichiometry-driven charge compensation and Ruddlesden–Popper defects in ferromagnetic high-entropy manganite thin films

High-entropy oxides (HEOs) originate from an innovative materials design strategy that stabilizes single-phase solid solutions despite the inclusion of multiple principal elements into a single cation sublattice. While prior efforts have largely focused on cation disorder, the impact of anion defects on the structure and properties of HEOs remains unexplored. Here, we examine the...

Rhodoliths can act as daily resolution paleotemperature archives in the Red Sea

Long-term, high-frequency temperature records are critical for evaluating the vulnerability of marine ecosystems to ongoing ocean warming. Commonly used paleoceanographic archives, such as corals and bivalves, face regional and ecological constraints. Rhodoliths, free-living coralline red algal nodules, are established and globally accessible alternatives, yet their complex three...

Smartphone movement data can reliably predict smoking lapses and cravings to enable timely smoking cessation support

Decades of research aiming to develop effective smoking interventions have identified triggers that contribute to failed quitting attempts including environmental (e.g. location), social (presence of other smokers), or internal (e.g. stress). Here, it is shown for the first time that passively collected movement data from smokers’ smartphones’ sensors (accelerometer, gyroscope...

Konstruksi Brand Identity Produk Lokal: Studi Strategi Komunikasi Pemasaran Pemerintah Negeri Morella

Marketing communication strategy is an important element in business development, particularly in addressing the challenges of marketing local products. This study aims to examine the marketing communication strategies implemented by the Morella Village Government and Village-Owned Enterprises (BUMDES) in improving the marketing of Morella nutmeg juice products produced by local...

PEDAGOGICAL AND PSYCHOLOGICAL APPROACHES TO THE DEVELOPMENT OF SELF-ESTEEM IN PRESCHOOL CHILDREN

This article provides a theoretical analysis of pedagogical and psychological approaches to the development of self-esteem in children attending preschool educational institutions. The psychological essence of the concept of self-esteem, its role in the personal development of preschool children, and its relationship with social adaptation and future educational success are...

Sustainable high-throughput microwell spectrophotometric methods for avapritinib quality control via charge-transfer complexation

Avapritinib (AVA) is a breakthrough targeted therapy as the first potent inhibitor approved for gastrointestinal stromal tumors (GIST) with PDGFRA D842V mutations. It lacks convenient analytical methods for routine quality control. This study addresses this gap by developing and validating two novel, green, high-throughput microwell spectrophotometric methods (MW-SPMs) for AVA...

Author Correction: Biophysical prediction of protein–peptide interactions and signaling networks using machine learning

Pengaruh Kepemimpinan Transformasional dan Motivasi Terhadap Kinerja Guru Melalui Employee Engagement pada SMP di Kecamatan Tarogong Kaler Kabupaten Garut

Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformasional dan motivasi terhadap kinerja guru dengan employee engagement sebagai variabel mediasi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei terhadap 76 responden. Teknik analisis data yang digunakan adalah Structural Equation Modeling berbasis Partial Least Square menggunakan...

Comparison of ventilation with second-generation supraglottic airway devices in a prospective randomized cadaver study

Second-generation supraglottic airway devices (SADs) are widely used alternatives to endotracheal intubation in both anesthesia and emergency airway management. The newly developed LT®evo represents a redesigned version of the established Laryngeal Tube Suction Disposable (LTS-D). This study compared the ventilatory performance of the LT®evo with endotracheal intubation and three...

Islamic Tolerance as an Ethics of Coexistence in Muḥammad ʿImārah’s Thought

Debates on Islamic tolerance continue to turn on the relation between doctrinal conviction, freedom of conscience, and public coexistence in plural societies. This article examines how Muḥammad ʿImārah’s Al-Samāḥah al-Islāmiyyah constructs Islamic tolerance as coexistence ethics. Using directed qualitative content analysis, the study analyzes textual units concerning Qur'anic non...