Integrated precise temperature regulation and electrophysiology sensing system for nanoplasmonic photothermal cardiac bradyarrhythmia therapy

Bradyarrhythmia is a potentially life-threatening disease. Current pharmacological and surgical treatments are limited by side effects and invasiveness, with an urgent need for safer and noninvasive therapeutic strategies. In this study, we develop a multifunctional regulating-sensing platform that integrates precise temperature regulation with simultaneous electrophysiological...

Breaking barriers: Validation of a Spanish oral health knowledge tool to enhance patient-provider communication

Sistem Pendukung Keputusan Pemilihan SMA Berbasis GIS Menggunakan Metode AHP-TOPSIS dan GPS Real-Time

Pemilihan Sekolah Menengah Atas (SMA) merupakan keputusan penting yang tidak cukup hanya mempertimbangkan jarak dari tempat tinggal. Faktor-faktor seperti akreditasi, biaya pendidikan, kelengkapan jurusan, fasilitas, dan kemudahan akses transportasi juga perlu diperhitungkan secara bersamaan. Penelitian ini mengembangkan Sistem Pendukung Keputusan (SPK) pemilihan SMA berbasis web...

Identification of tumor-promoting functions of the Homeobox family transcription factor MSX1 in cervical cancer

Cervical cancer (CC) remains a leading cause of cancer-related mortality among women, particularly in underdeveloped or developing countries lacking adequate screening programs. Despite being highly preventable through HPV vaccinations and screening tests, and highly treatable when detected early, CC continues to pose a significant health burden. MSX1, a transcription factor of...

Mapping the landscape of psychological literature on threat from 1961 to 2023 through structural topic modeling

Artificial intelligence-enhancement of flow cytometry data accelerates the identification of measurable residual chronic lymphocytic leukemia

Flow cytometry (FC) is essential for detecting measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL), but its use is limited by the expertise and time required for manual analysis. We developed an artificial intelligence (AI) pipeline, Clustering/Classification of All Events, Dimensionality reduction, Downsampling, and Aberrancy Scaling (CCADDAS), to...

Prevalence and determinants of cigarette smoking and smoking frequency among people with tuberculosis in Lesotho: Evidence from a nationwide cross-sectional survey

“Breast is Best”: does this also apply to neonatal neuroprotection?

Large-scale statistical dissection of sequence-derived biochemical features distinguishing soluble and insoluble proteins

Mechanical response of high-porosity rocks under high triaxial confining pressure and experimental study of indentation tests

Multilingual Strategies for Teaching English: Perspectives from Graduate Students in Multicultural Contexts

The increasing linguistic and cultural diversity of English classrooms requires pedagogical strategies that can support learners with different language backgrounds. However, graduate students’ perspectives as emerging English language educators remain underexplored in multilingual pedagogy research. This study aimed to examine how graduate students perceive and apply...

Clinicopathological features and ethnic disparities of melanoma in the United Arab Emirates: 2017–2025

Age, emotional burden and deep brain stimulation electrode location shape Parkinson’s disease quality of life

Postoperative quality-of-life (QoL) outcomes after subthalamic deep brain stimulation in Parkinson’s disease vary widely. Previous studies based on PDQ-39 summary scores have reported opposing relationships between baseline and postoperative QoL, reflecting analytic variability, measurement noise, and limited feature scope. To address these inconsistencies, we analyzed 130...

Youth’s mental health journeys through the COVID-19 pandemic using arts-based methods in virtual environments

Precision timekeeping with atomic clocks: evolution and future directions

Accurate timekeeping is foundational to modern society, supporting critical technologies such as global navigation satellite systems (GNSS), high-frequency financial trading, synchronization of communication networks, and the realization of SI base units. Here we review the evolution of timekeeping, with a particular emphasis on atomic clocks and their applications. We describe...

GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice

Opioid addiction is characterized by compulsive drug seeking and use, accompanied by pain and heightened pain sensitivity (hyperalgesia) during withdrawal, yet the underlying neural mechanisms remain incompletely understood, especially for fentanyl. Using whole-brain Fos mapping and network analysis, we found that the periaqueductal gray is a central hub brain region engaged...

Mental health and suicide literacy among school nurses in Japan: A cross-sectional study

Identification of a metabolic–immune crosstalk in Still’s disease: monocyte/macrophage-derived immunometabolite itaconate dictates hepatic immunopathology via the CXCL10–CD8 T cell axis

Still’s disease (SD) is a chronic and systemic autoinflammatory disorder, with the possibility of resulting in life-threatening complications, including macrophage activation syndrome (MAS). The metabolic–immune interplay underlying the immunopathology of SD/MAS remains largely unexplored. In this study, we identified itaconate — a myeloid cell-specific metabolite derived from...

Struktur Kebahasaan dan Fungsi Retoris Uslūb Nidā’ dalam Al-Qur`an: Kajian Balāgah dan Tafsir

This study examines uslūb nidā’ (the rhetorical vocative style) in the Qur`an, addressing two research questions: (1) what are the linguistic structural forms of uslūb nidā’ in the Qur`an, and (2) what are the rhetorical functions of uslūb nidā’ from the perspectives of balāghah and Qur`anic exegesis? The study adopts a qualitative approach through library research. Seven verses...

Changes in tobacco sales before, during, and after the COVID-19 pandemic in Japan: An interrupted time series analysis

Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis

Baseline endocrine factors influencing live birth outcomes in Chinese infertile women undergoing their first fresh IVF cycle: A multistate model-based cohort study

From cheap entertainment to expensive pleasure: Cinema-going habits and motivations of young people in Türkiye

Clinical characteristics and management strategies in adult foreign-body airway obstruction: A retrospective cohort study

Correction: Earliest evidence for invasive mitigation of dental caries by Neanderthals

Progress and gaps in childhood immunization among two-year-olds in Ghana (1993–2022): A trend and equity analysis

Pre-analytical variables affecting breast cancer biomarker expression: A controlled single-specimen study of fixation duration, cold ischemia time, and fixative preparation in a low-resource setting

Association between the triglyceride-glycated hemoglobin index and diabetes risk among patients with Non-alcoholic fatty liver disease: A longitudinal cohort study

Blue carbon projects must uphold the land and sea rights of coastal peoples

Scalable Boltzmann generators for equilibrium sampling of large-scale materials

Generating equilibrium ensembles of structures is essential for modeling molecules and materials, yet traditional simulators like molecular dynamics suffer from limited sampling efficiency. Boltzmann Generators introduced the concept of one-shot deep learning for equilibrium sampling, but scalability to large systems has remained a major challenge. Here, we overcome this scaling...